The tree scale is shown as expected number of substitutions per site. 1.6.12 web server, and the consensus tree was visualized with the iTOL v. 7.450), the phylogeny was built with the IQ-TREE v. Nucleotide sequences were aligned with MAFFT (FFT-NS-2, v. Representative monkeypox virus genomes were selected from both the Congo basin and the west African clades. It is most similar to monkeypox virus genomes collected from a small international outbreak in 2017-18 (see Figure 1), and only differs from one of these sequences, MT903343.1, by fewer than 100 out of over 197,000 nucleotide bases.įigure 1: Phylogenomic tree of monkeypox virus genomes. This new genome sequence, produced from a Massachusetts isolate, was submitted to GenBank by the Division of High-Consequence Pathogens and Pathology of the US Centers for Disease Control and Prevention. Having viral genome data freely and widely available in GenBank enables researchers to explore how this virus differs from viruses isolated and sequenced in the past. This particular outbreak has been identified as due to a virus from the west African clade which is often associated with milder disease and, in this case, human-to-human spread is suspected. Genetically, monkeypox viruses cluster into two groups: the Congo basin and the west African clade. Monkeypox is classified as a zoonotic disease where transmission of the virus is usually due to animal-human contact. Several cases of monkeypox have been identified in geographically widespread countries. The first complete genome sequence of the current monkeypox virus (MPXV) outbreak (isolate name MPXV_USA_2022_MA001) is now available with accession ON563414 in GenBank, a public database of DNA sequences hosted by the National Center for Biotechnology Information (NCBI) at the National Library of Medicine (NLM).
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |